terça-feira, 6 de maio de 2014

Links para Entender a Teoria Atual Sobre Self-Replication

(from: https://www.youtube.com/watch?v=gHbYJfwFgOU

+633495 once again brandishes his empty challenge:
"Could we have even one resident evo-nerd please cite a paper where a ribozyme has been shown to catalyze the type of polymerization required for RNA replication"

Try any recent ones by Gerald F Joyce for your mental size, Titbits:

Robertson MP, Joyce GF. (2014) Highly efficient self-replicating RNA enzymes.  Chem Biol. 21: 238-45.

Ferretti AC, Joyce GF. (2013) Kinetic properties of an RNA enzyme that undergoes self-sustained exponential amplification.  Biochemistry. 52: 1227-35.  

Lam, BJ & Joyce, GF (2009) Autocatalytic aptazymes: ligand-dependent exponential amplification of RNA. Nature Biotechnol. 27: 288-92. 

Lincoln, TA & Joyce, GF (2009) Self-sustained replication of an RNA enzyme. Science. 323: 1229-32.

Voytek, SB & Joyce, G.F. (2007) Emergence of a fast-reacting ribozyme that is capable of undergoing continuous evolution. Proc. Natl. Acad. Sci. USA 104: 15288–93.

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